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US 2011/0212023 A1Published application
TADG-15: an extracellular serine protease overexpossed in carcinomas
OwnerTimothy J. O'Brien, Hirotoshi Tanimotoinventors
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OwnerTimothy J. O'Brien, Hirotoshi Tanimotoinventors
Estimating the term…
The present invention provides DNA encoding a TADG-15 protein as well as a TADG-15 protein. Also provided is a vector capable of expressing the DNA of the present invention adapted for expression in a recombinant cell and regulatory elements necessary for expression of the DNA in the cell. The present invention further provides for methods of inhibiting TADG-15 expression and/or protease activity, methods of detecting TADG-15 mRNA and/or protein and methods of screening for TADG-15 inhibitors. Additionally, the present invention provides for cell-specific targeting via TADG-15 and methods of vaccinating an individual against TADG-15. The methods described are useful in the diagnosis, treatment and prevention of cancer, particularly breast and ovarian cancer.
A vector comprising a DNA encoding a tumor antigen-derived gene (TADG-15) protein and regulatory elements necessary for expression of the DNA in a cell;
A method of inhibiting a TADG-15 protein in a cell, comprising:
An immunogenic composition, comprising an immunogenic fragment of a TADG-15 protein and an appropriate adjuvant.
A method of screening for compounds that inhibit TADG-15, comprising:
Dependencies are inferred from the claim text.