Photosynthetic microorganisms enriched in selenium using selenohydroxy acid compounds, used thereof in nutrition, cosmetics and pharmacy
AssigneeEco Solution
InventorsBernard Kudla, Frédéric De Baene, Marc Lange
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Abstract
The invention relates to the enrichment of photosynthetic microorganisms in organic selenium using selenohydroxy acid compounds, in particular 2-hydroxy-4-methylselenobutanoic acid, in D or L form, or an enantiomer, salt or ester or amide derivative of these compounds, and also to the use of the microorganisms thus enriched in animal or human nutrition, in cosmetics or in pharmacy.
Claims23
Method for enriching a photosynthetic microorganism in organic selenium, wherein said photosynthetic microorganism is cultured in a medium comprising a compound of selenohydroxy acid type.
Chlorophycea enriched in organic selenium, wherein its content of organic selenium in the form of selenomethionine represents more than 50%, preferably more than 70%, more preferably more than 80%, and even more preferably more than 90%, of the total mass of selenium that it contains.
Chlorophycea enriched in organic selenium, wherein its content of organic selenium in the form of selenomethionine is greater than 100 μgSe/g, preferably greater than 200 μSe/g, more preferably greater than 500 μgSe/g, and even more preferably greater than 1000 μgSe/g by dry weight.
Cyanophycea enriched in organic selenium, wherein its content of organic selenium in the form of selenomethionine represents more than 50%, preferably more than 70%, more preferably more than 80%, and even more preferably more than 90% of the total mass of selenium that it contains.
Cyanophycea enriched in organic selenium, wherein its content of organic selenium in the form of selenomethionine is greater than 100 μgSe/g, preferably greater than 200 μgSe/g, more preferably greater than 500 μgSe/g, and even more preferably greater than 1000 μgSe/g by dry weight.
Culture medium for a photosynthetic micro-organism, wherein it comprises one or more compounds of selenohydroxy acid type of formula (I):
- in which:
- n represents 0, 1 or 2;
- R1 is an OH, OCOR3, OPO3H2, OPO3R4R5 or OR6group;
- R2 is an OH, R3 NHR7, S-cysteinyl or S-glutathionyl group;
- it being understood that, when n=1 and R2 is OH, then R1 cannot be OH;
- R3 is an alkoxyl, S-cysteinyl or S-glutathionyl group, or a group chosen from the following:
- OR4 is a (C1-C26) alkoxyl group, or a group chosen from the following:
- OR5 is a (C1-C26) alkoxyl group or a group chosen from the following:
- OR6 is a pyruvate, lactate, citrate, fumarate, maleate, myristate, palmitate, stearate, palmitoleate, oleate or linoleate group, a natural fatty acids group or a 13-cis-retinoate group;
- R7 is an H or (C1-C26) alkyl group, a natural amino acid or a natural amine.
Dependencies are inferred from the claim text.