Pharmaceutical compositions and methods for the treatment of cancer
AssigneeUrifer Ltd.
InventorsUri Nir, Sally Shpungin, Etai Yaffe, Moshe Cohen
Life of this patent
Estimating the term…
Abstract
Provided is a pharmaceutical composition including as an active component a compound of formula (I): wherein X and (R1)n are as defined, and a physiological acceptable carrier. Also provided is a method for treating cancer including administering to an individual in need of such treatment an effective amount of the presently described pharmaceutical composition.
Claims9
A pharmaceutical composition comprising as an active component a compound of formula (I):
- X is selected from the following:
- wherein R1 is independently selected from H, F, Cl, Br, I or a C1-5 linear or branched alkyl;
- n is 1, 2, 3, 4 or 5;
- R2 is N(R)2, R being independently hydrogen or linear or branched C1-5alkyl group;
- R3 is a linear or branched C1-5alkyl group;
- R4 is a group of formula
- R5 being a 5- or 6-membered aromatic or non-aromatic ring optionally having one, two or three heteroatoms selected from O, N or S;
- R6 being a 5- or 6-membered aromatic or non-aromatic ring optionally having one, two or three heteroatoms selected from O, N or S optionally having one or two substituents independently selected from halogen and a linear or branched C1-5alkyl group;
- Z is selected from O or S;
- Y is C—H or N;
- and A is a 5- or 6-membered fused aromatic or non aromatic ring optionally being a heterocyclic ring comprising 1 to 3 heteroatoms selected from O, N or S;
- and a physiological acceptable carrier.
A method for treating cancer, comprising administering to an individual in need thereof a therapeutically effective amount of a pharmaceutical composition comprising as an active component a compound of formula (I):
- X is selected from the following:
- wherein R1 is independently selected from H, F, Cl, Br, I or a C1-5 linear or branched alkyl;
- n is 1, 2, 3, 4 or 5;
- R2 is N(R)2, R being independently hydrogen or linear or branched C1-5alkyl group;
- R3 is a linear or branched C1-5alkyl group;
- R4 is a group of formula
- R5 being a 5- or 6-membered aromatic or non-aromatic ring optionally having one, two or three heteroatoms selected from O, N or S;
- R6 being a 5- or 6-membered aromatic or non-aromatic ring optionally having one, two or three heteroatoms selected from O, N or S optionally having one or two substituents independently selected from halogen and a linear or branched C1-5alkyl group;
- Z is selected from O or S;
- Y is C—H or N;
- and A is a 5- or 6-membered fused aromatic or non aromatic ring optionally being a heterocyclic ring comprising 1 to 3 heteroatoms selected from O, N or S;
- for the preparation of a medicament for the treatment of cancer.
Dependencies are inferred from the claim text.