DELIVERY OF siRNAs
OwnerTariq M. Ranainventor
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Abstract
The present invention provides siRNA delivery methods use in vivo or in vitro. The delivery methods include conjugation with delivery peptides and mixing with dendrimers.
Claims16
A method for delivering an siRNA or engineered RNA precursor to a cell, the method comprising:
- (a) obtaining a cell
- (b) conjugating at least one delivery peptide to an siRNA or engineered RNA precursor, thereby forming a peptide-conjugate;
- and
- (c) contacting the cell with the peptide-conjugate.
A method for delivering an siRNA to a cell, the method comprising:
- (a) obtaining a cell;
- (b) forming a mixture comprising an siRNA and at least one dendrimer;
- and
- (c) contacting the cell with the mixture, thereby delivering the siRNA to the cell.
A kit for conjugating a delivery peptide to a siRNA, comprising the delivery peptide and an activating agent.
A kit for preparing an siRNA delivery mixture comprising a dendrimer and instructions for use in mixing with an siRNA.
An siRNA delivery mixture comprising a dendrimer.
An siRNA or engineered RNA precursor conjugated to a delivery peptide.
Dependencies are inferred from the claim text.