Methods for the early diagnosis of ovarian cancer
OwnerTimothy J. O'Brien, Martin J. Cannon +3inventors
InventorsTimothy J. O'Brien, Martin J. Cannon, Alessandro Santin, John Beard, Kazushi Shigemasa
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Abstract
The present invention discloses the protease hepsin is specifically over-expressed in ovarian and other malignancies. A number of hepsin peptides can induce immune responses to hepsin, thereby demonstrating the potential of these peptides in monitoring and the development of immunotherapies for ovarian and other malignancies. There is also provided a hepsin protein variant that is useful as a marker for ovarian cancer cells, prostate cancer cells or kidney cancer cells.
Claims20
An isolated DNA encoding a hepsin protein variant, said variant protein comprising an amino acid sequence shown in SEQ ID NO. 195 or a peptide variant thereof.
An isolated and purified hepsin protein variant with an amino acid sequence shown in SEQ ID NO. 195 or a hepsin protein variant peptide thereof with an amino acid sequence shown in SEQ ID NO:
- 196.
The method of claim, further comprising a therapeutic moiety.
A method of producing immune-activated cells directed toward a hepsin protein variant, comprising:
- exposing dendritic cells to a hepsin protein variant with a sequence shown in SEQ ID NO:
- 195 or peptide variant therefrom, wherein the exposure activates the immune cells and produces immune-activated cells directed toward the hepsin protein variant.
Dependencies are inferred from the claim text.