Dkat cell line, a model for human triple-negative breast cancer
AssigneeDuke University; The Regents of the University of California
InventorsVictoria L. Seewaldt, Nicholas C. D'Amato, Julie H. Ostrander
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Abstract
The present invention provides a human triple-negative breast cancer cell line designated DKAT. The DKAT cell line has a marker profile of high expression of Snail-1 and Snail-2 (Slug); and a p53 mutation in exon 8 at codon 273 (CGT>CAT). The present invention further provides methods of using the DKAT cell line.
Claims27
A cell line deposited under ATCC Accession No. PTA-10322.
A human triple-negative breast cancer cell line, wherein the cell line comprises the following marker profile:
- high expression of Snail-1 and Snail-2 (Slug);
- and
- a p53 mutation in exon 8 at codon 273 (CGT>CAT).
A human triple-negative breast carcinoma cell line, wherein a cell of said cell line produces a solid carcinoma upon subcutaneous implantation or injection into a non-human mammal, said cell line comprising the following marker profile:
- high expression of Snail-1 and Snail-2 (Slug);
- and
- a p53 mutation in exon 8 at codon 273 (CGT>CAT).
Dependencies are inferred from the claim text.