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AssigneeNatural Pharmacia International, Inc.
InventorsDavid Y-W Lee, Xiao-Shen Ji, James A. Raleigh
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The invention features a class of 2-nitroimidazole compounds with a secondary basic nitrogen atom and a linker bearing one or more therapeutic agents, cytotoxic agents, detectable labels, or chelating groups. In particular, the invention provides 2-nitroimidazole compounds containing a cluster of boron atoms for use in boron neutron capture therapy (BNCT). The 2-nitroimidazole compounds can be used to treat hypoxic conditions, including, e.g., cancer, inflammation, and ischemia. The weakly basic 2-nitroimidazole compounds target to hypoxic tissue and provide increased tissue concentration overall.
-39. (canceled)
A compound having the structure of formula I and pharmaceutically acceptable salts thereof
The compound of claim 46 and pharmaceutically acceptable salts thereof, wherein said radiolabel is 18F or 123I.
Dependencies are inferred from the claim text.