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OwnerJonathan A. Terrett, Josephine M. Cardarelli +3inventors
InventorsJonathan A. Terrett, Josephine M. Cardarelli, Chetana Rao-Naik, Bingliang Chen, David J. King
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The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to B7H4 with high affinity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided, immunoconjugates, including antibody-drug conjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for treating cancer.
An antibody-partner molecule conjugate comprising a human monoclonal antibody, or an antigen-binding portion thereof, wherein the antibody binds human B7-H4 and the antibody-partner molecule conjugates exhibits at least one of the following properties:
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An antibody-partner molecule conjugate comprising a monoclonal antibody, or antigen binding portion thereof, which binds an epitope on human B7-H4 recognized by a reference antibody, wherein the reference antibody comprises:
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Dependencies are inferred from the claim text.