Intravitreal injection system having coaxial cannulae and use thereof

An ophthalmic injection system having coaxial cannulae comprising:

• a first syringe body configured to accommodate a cannula positioning assembly;
• a first substantially non-flexible cannula formed at or attached to a distal end of the first syringe body to provide guidance to a second cannula into an interior of a patient's eye globe or a posterior segment of a patient's eye, wherein the first cannula is long enough to penetrate one or more outer layers of the patient's eye and the first cannula has an inner diameter to properly guide the second cannula;
• the cannula positioning assembly for positioning the second cannula into the interior of a patient's eye globe or the posterior segment of a patient's eye through the first cannula;
• a second syringe body for accommodation and infusion of a pharmaceutical composition, the second syringe body being placed outside the first syringe body;
• wherein a conduit connects the second syringe body to the second cannula to allow passage of the pharmaceutical composition to the tip of the second cannula;
• and
• a plunger contained within the second syringe body for injecting the pharmaceutical composition through the conduit and the second cannula to a surgical site.

A method for delivery of a pharmaceutical composition into a patient's eye comprising the steps of:

• providing a first syringe body, which has a first cannula formed at or attached to one end of the first cannula;
• further providing a second syringe body, which has a second cannula formed at or attached to one end of the second syringe body, wherein the second syringe body and second cannula are contained within the first syringe body and first cannula;
• inserting the first cannula into the patient's eye, such that the first cannula penetrates one or more outer layers of the patient's eye;
• inserting the second cannula through the first cannula into the patient's eye towards a surgical site;
• injecting the pharmaceutical composition, which is contained in the second syringe body, to a surgical site;
• and
• removing the first and second cannulae from the patient's eye.

A method for delivering a pharmaceutical composition into an interior of a patient's eye globe or a posterior segment of a patient's eye, the method comprising the steps of:

• inserting a first cannula formed at or attached to a first syringe body to a pre-determined position of the patient's eye such that the first cannula penetrates one or more outer layers of the patient's eye, thereby making an incision to allow insertion of a second cannula into the interior of the patient's eye globe or the posterior segment of the patient's eye, wherein the first syringe body is configured to accommodate a cannula positioning assembly for positioning the second cannula;
• positioning the second cannula at a predetermined surgical site by manipulating the cannula positioning assembly, wherein the second cannula is connected to a second syringe body apart from the first syringe body through a conduit;
• injecting the pharmaceutical composition from the second syringe body through the conduit and second cannula to a surgical site;
• and
• removing the first and second cannulae from the patient's eye.