INHIBITORS OF THE CHEMOKINE RECEPTOR CxCR3

A 3-(amido or sulphamido)-4-(4-substituted-azinyl)benzamide or benzsulphonamide compound of formula I

• wherein
• Q and Q1 are independently CO or SO2;
• Y is CO or SO2;
• X is halo;
• m is 1, 2 or 3;
• R1 is (optionally substituted (aromatic or lower cyclyl)) lower alkyl C1-3;
• R2, R4 and R6 are independently H or optionally substituted lower alkyl;
• R3 is optionally substituted aromatic group;
• A is CH or N, or A and R5 taken together form a 4-7 membered spiro azaheterocyclyl of the following formula
• n and p are independently 0, 1, 2, 3, 4 or 5, so long as n and p≧2 but ≦5;
• R5 is JGZ, R8R7NQ1 lower alkyl or optionally substituted 3-7 membered azaheterocyclyl;
• Z is bond, CO or SO2;
• G is lower alkyl, C3-7 cycloalkyl or 3-7 membered heterocyclyl;
• and
• J is aromatic group, lower alkoxycarbonyl, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, lower alkoxy, R8R7N or optionally (lower alkyl or halo) substituted 3-7 membered heterocyclyl;
• R7 and R8 are independently H or lower alkyl;
• R9 and R10 are independently H or lower alkyl;
• or
• a pharmaceutically acceptable salt, solvate, N-oxide, quarternary derivative or prodrug thereof, or any combination thereof.