Active pharmaceutical ingredient on a solid support, amorphous and with an improved solubility

A method for producing a combination preparation comprising an active pharmaceutical ingredient (API) and a pharmaceutically acceptable solid support, the method comprising:

• a) providing a suspended solution comprising:
• a solid support which is in a hydrophilic particulate form and comprises a material selected from the group consisting of silicic acid, aluminum hydroxide and titanium hydroxide;
• an API having both, at least one hydrophobic structural moiety causing the API to have low solubility in water or in an aqueous solution, and multiple hydrophilic groups arranged to form multiple intermolecular interactions to said solid support involving polar or ionic or hydrogen bonding, wherein the hydrophilic groups of the API are independently equal or different and comprise at least one of the groups consisting of OH- and halogen-groups;
• and
• an organic solvent dissolving said API;
• b) removing said organic solvent by evaporation;
• and
• c) obtaining a combination preparation having said API bound to said solid support by adsorption, wherein a major proportion of said API is in the amorphous state.