Organo-gel formulations for therapeutic applications
AssigneeMediQuest Therapeutics, Inc.
InventorFrederick J. Dechow
Life of this patent
Estimating the term…
Abstract
A composition suitable for the local delivery of cosmetic and/or pharmaceutical agents into the skin containing at least two biocompatible organic solvents, a polar lipid, a surfactant, water, urea and a thickener wherein the organic solvents include an ester and a dihydric and/or polyhydric alcohol is provided. Also disclosed are compositions that further contain a cosmetic and/or pharmaceutical agent, along with the preparation and use thereof
Claims34
A composition suitable for the delivery of at least one cosmetic agent or pharmaceutical agent or both through the skin or nails of a mammal, which comprises two biocompatible organic solvents, 6 to 30% by weight of lecithin, 0.5 to 19% by weight of at least one or more surfactant, wherein said surfactant comprises a docusate, 40 to 65% by weight of water, 1 to 15% by weight of urea and 0.05 to 5% by weight of thickener;
- wherein the organic solvents comprise 2 to 30% of isopropyl myristate and 0.5 to 20% of glycerol.
A method of making a composition suitable for cutaneous delivery of at least one cosmetic agent or a pharmaceutical agent or both wherein said composition comprises at least one cosmetic agent or a pharmaceutical agent or both, two biocompatible organic solvents 6 to 30% by weight of lecithin, 0.5 to 19% by weight of at least one or more surfactant, wherein said surfactant comprises a docusate, about 40 to about 65% by weight water, 1 to 15% by weight of urea and 0.5 to 5% by weight of a thickener;
- wherein the organic solvents comprise 2 to 30% of isopropyl myristate and 0.5 to 20% of glycerol;
- and which method comprises:
- a. dissolving 6 to 30% by weight of lecithin, at least in two biocompatible organic solvents comprising isopropyl myristate and glycerol;
- b. adding 0.5 to 19% by weight of one or more surfactants to the composition of step (a);
- wherein said one or more surfactants comprises a docusate;
- c. dissolving a cosmetic agent or pharmaceutically active compound or both in the solvent-polar lipid, surfactant mixture of step (b);
- d. adding 1 to 15% by weight of urea and 0.5 to 5% by weight of thickener(s) to water;
- and
- e. combining the composition from c and d and optionally adjusting the pH to about 5.5 to about 7.5.
A method of making a composition suitable for cutaneous delivery of at least one cosmetic agent or a pharmaceutical agent or both wherein said composition comprises at least one cosmetic agent or a pharmaceutical agent or both, two biocompatible organic solvents, 6 to 30% by weight of lecithin, 0.5 to 19% by weight of at least one or more surfactant, wherein said surfactant comprises a docusate, 40 to 65% by weight water, 1 to 15% by weight of urea and 0.5 to 5% by weight of a thickener;
- wherein the organic solvents comprise 2 to 30% of isopropyl myristate and 0.5 to 20% of glycerol;
- and which method comprises:
- a. dissolving 16 to 30% by weight of lecithin , at least in two biocompatible organic solvents comprising isopropyl myristate and glycerol;
- b. adding 0.5 to 19% by weight of one or more surfactants to the composition of step (a);
- wherein said one or more surfactants comprises a docusate;
- c. adding 1 to 15% by weight of urea and 0.5 to 5% by weight of thickener(s) to water;
- d. dissolving a cosmetic agent or pharmaceutically active compound or both in the thickened aqueous urea;
- and
- e. combining the composition from (b) and (d) and optionally adjusting the pH to about 5.5 to about 7.5.
Dependencies are inferred from the claim text.