Compounds and methods for modulating protein trafficking
AssigneeFoldRx Pharmaceuticals, Inc.
InventorsChristine Bulawa, James Fleming
Life of this patent
Estimating the term…
Abstract
Disclosed are compositions and methods for modulating protein trafficking and treating or preventing disorders characterized by impaired protein trafficking. Also disclosed are methods for producing a protein and identifying compounds that rescue protein trafficking defects.
Claims26
A method of treating or preventing a disorder characterized by impaired protein trafficking, the method comprising administering to a subject in need thereof an effective amount of a compound of Table 2 or a pharmaceutically acceptable derivative thereof or Table 3 or a pharmaceutically acceptable derivative thereof.
A composition comprising (i) a compound of Table 2 or a pharmaceutically acceptable derivative thereof or Table 3 or a pharmaceutically acceptable derivative thereof, and (ii) one or more of donepezil hydrochloride (Aracept), rivastigmine tartrate (Exelon), tacrine hydrochloride (Cognex), or galantamine hydrobromide (Reminyl).
A method of inhibiting alpha synuclein-mediated cellular toxicity, the method comprising contacting a cell expressing a toxicity-inducing amount or form of alpha synuclein with an effective amount of a compound of Table 2 or a pharmaceutically acceptable derivative thereof or Table 3 or a pharmaceutically acceptable derivative thereof.
A method of producing a protein, the method comprising:
- culturing a cell in the presence of a compound of Table 2 or a pharmaceutically acceptable derivative thereof or Table 3 or a pharmaceutically acceptable derivative thereof;
- and
- purifying a protein produced by the cell,
- wherein the culturing of the cell in the presence of the compound results in enhanced production of the purified protein as compared to culture of the cell in the absence of the compound.
Dependencies are inferred from the claim text.