Ccl18 and ccl3 methods and compositions for detecting and treating cancer
AssigneeUniveristy of Vermont and State Agricultural College
InventorsMarcus Bosenberg, Christopher Matthew Bradbury, Ravikumar Muthuswamy
Life of this patent
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Abstract
The invention relates to methods of treating cancer by administering one or more chemokines that are downregulated in cancerous cells. More specifically, the invention provides methods for treating or preventing cancers such as malignant melanoma by administering a chemokine such as CCL18 and/or CCL3. The invention further provides methods for diagnosing cancer such as melanoma.
Claims26
A method of treating cancer in a subject, the method comprising:
- administering to a subject in need of such treatment a CCL18 modulator and/or a CCL3 modulator in an amount effective to increase the level of a CCL18 molecule and/or a CCL3 molecule in a cell or tissue of the subject to inhibit cancer in the subject.
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A pharmaceutical composition comprising a CCL18 modulator and/or a CCL3 modulator and a pharmaceutical carrier.
22-51. (canceled)
A method for monitoring response to a cancer treatment in a subject with cancer, the method comprising:
- detecting a level of a CCL18 molecule in a first sample obtained from the subject,
- administering the cancer treatment to the subject,
- detecting the level of the CCL18 molecule in a second sample, wherein the second sample is obtained from the subject after treatment and at a time later than the first sample, and
- comparing the level of the CCL18 molecule in the first sample with the level of the CCL18 molecule in the second sample, wherein a higher level of the CCL18 molecule in the second sample than in the first sample indicates that the subject is responsive to the cancer treatment.
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Dependencies are inferred from the claim text.