US 2010/0305031 A1 · PEPTIDE HAVING AN EXTENDING ACTION FOR HALF-LIFE OF OBJECT PEPTIDE IN PLASMA

Abstract

A peptide of the following (I) or (II). (I) a peptide represented by the formula B, A-B, B-C or A-B-C in which A, B and C each is represented by the following (1), (2) and (3) and, when it is bonded to other object peptide, it is able to extent the half-life in plasma as compared with the object peptide where the physiological activity of the object peptide is still retained. (II) a peptide comprising a reversed sequence of the peptide of (I); a sequence which is represented by A-B in (I) and A or B is reversed; a sequence which is represented by B-C in (I) and B or C is reversed; or a sequence which is represented by A-B-C in (I) and A, B, C, A and B, B and C or A and C is reserved. (1) A is a peptide comprising 1 to 14 of any amino acid(s) (2) B is a peptide represented by the formula 1: (Wk-Xl-Y-Zm-Wn)-(Wo-Xp-Y-Zq-Wr)s (In the formula 1, W is a basic amino acid; X and Z are any amino acids; Y is an acidic amino acid; k is 1 or 2; l is an integer of 4≧l≧0; m is an integer of 2≧m≧0; 4≧l+m≧0; n is 1 or 2; o is 1 or 2; p is an integer of 4≧p≧0; q is an integer of 2≧q≧0; 4≧p+q≧0; r is 1 or 2; and s is 0 or 1.) (3) C is a peptide comprising 2 to 14 of any amino acids.

Claims68

Dependent claims

A peptide of the following (I) or (II).

(I) a peptide represented by the formula B, A-B, B-C or A-B-C in which A, B and C each is represented by the following (1), (2) and (3) and, when it is bonded to other object peptide, it is able to extent the half-life in plasma as compared with the object peptide where the physiological activity of the object peptide is still retained.
(II) a peptide comprising a reversed sequence of the peptide of (I);
a sequence which is represented by A-B in (I) and A or B is reversed;
a sequence which is represented by B-C in (I) and B or C is reversed;
or a sequence which is represented by A-B-C in (I) and A, B, C, A and B, B and C or A and C is reserved.
(1) A is a peptide comprising 1 to 14 of any amino acid(s)
(2) B is a peptide represented by the formula 1:
(Wk-Xl-Y-Zm-Wn)-(Wo-Xp-Y-Zq-Wr)s
(In the formula 1, W is a basic amino acid;
X and Z are any amino acids;
Y is an acidic amino acid;
k is 1 or 2;
l is an integer of 4≧l≧0;
m is an integer of 2≧m≧0;
4≧1+m≧0;
n is 1 or 2;
o is 1 or 2;
p is an integer of 4≧p≧0;
q is an integer of 2≧q≧0;
4≧p+q≧0;
r is 1 or 2;
and s is 0 or 1.)
(3) C is a peptide comprising 2 to 14 of any amino acids.

20 more elements

A peptide represented by the formula B, A-B, B-C or A-B-C and, in the formula, A, B and C each is the following (1) or (2) and, when it is bonded to other peptide, its half-life is able to be extended where the physiological activity is still retained.

(1) A is an amino acid sequence of one or more amino acid numbers 1 to 4 continuing to B in SEQ ID No:
34 or an amino acid sequence where one or some amino acid(s) in the above amino acid sequence is/are deleted, substituted and/or added;
B is an amino acid sequence of amino acid numbers 5 to 9 in SEQ ID No:
34 or an amino acid sequence where one or some amino acid(s) in the above amino acid sequence is/are deleted, substituted and/or added;
and
C is an amino acid sequence of one or more amino acid numbers 10 to 17 continuing to B in SEQ ID No:
34 or an amino acid sequence where one or some amino acid(s) in the above amino acid sequence is/are deleted, substituted and/or added.
(2) A is an amino acid sequence of one or more amino acid numbers 1 to 8 continuing to B in SEQ ID No:
67 or an amino acid sequence where one or some amino acid(s) in the above amino acid sequence is/are deleted, substituted and/or added;
B is an amino acid sequence of amino acid numbers 9 to 13 in SEQ ID No:
67 or an amino acid sequence where one or some amino acid(s) in the above amino acid sequence is/are deleted, substituted and/or added;
and
C is an amino acid sequence of one or more amino acid numbers 14 to 17 continuing to B in SEQ ID No:
67 or an amino acid sequence where one or some amino acid(s) in the above amino acid sequence is/are deleted, substituted and/or added.

11 more elements

Dependencies are inferred from the claim text.

Peptide having an extending action for half-life of object peptide in plasma

Life of this patent

Peptide having an extending action for half-life of object peptide in plasma

Life of this patent

Abstract

Claims68