Methods of inhibiting calcineurin with apoe analogs
AssigneeCognosci, Inc.
InventorsMichael P. Vitek, Feng-Qiao Li
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Abstract
The present invention provides a method of modulating calcineurin activity in a cell by contacting the cell with at least one ApoE analog. Methods of treating various disorders associated with calcineurin activity using one or more ApoE analogs are also disclosed. In particular, the present invention provides a method of reducing demyelination and promoting remyelination in a subject. Methods of treating spinal cord or nerve injury in a subject are also described.
Claims50
A method of modulating calcineurin activity in a cell comprising contacting the cell with at least one ApoE analog.
A method of promoting remyelination in a subject in need thereof comprising administering an effective amount of at least one ApoE analog to the subject, wherein myelination is enhanced in the subject following administration of the at least one ApoE analog.
A method of treating multiple sclerosis in a subject in need thereof comprising administering an effective amount of at least one ApoE analog to the subject, wherein the at least one ApoE analog contains a sequence selected from the group consisting of SEQ ID NO:
- 3, SEQ ID NO:
- 4, SEQ ID NO:
- 6, and SEQ ID NO:
- 7.
A method of treating spinal cord injury or nerve injury in a subject in need thereof comprising administering an effective amount of at least one ApoE analog to the subject.
A method of promoting the survival and/or proliferation of oligodendrocyte precursor cells comprising treating the oligodendrocyte precursor cells with at least one ApoE analog, wherein the number of oligodendrocyte precursor cells is increased following treatment with the at least one ApoE analog.
Dependencies are inferred from the claim text.