Copolymers suitable for use in corneal bandages
AssigneesUniversity of Southampton, The University Court of the University of Edinburgh
InventorsGuilhem Tourniaire, Mark Bradley, Albert Liberski
Life of this patent
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Abstract
Disclosed is a polymer having an affinity for corneal cells such that it can be used as a substrate for the growth of corneal cells, and so is suitable for use in a corneal bandage, especially in the form of a contact lens in which at least the cornea contacting surface is composed of the polymer. The substrate with an affinity for corneal cells is a copolymer comprising units -(A)- and -(B)- in which the units A are derived from aminoalkyl (alkyl)acrylates and the units B are derived from aryloxy, alkoxy or hydroxyalkyl (alkyl)acrylates, and (alkyl)acrylic acids.
Claims29
A method of corneal therapy, comprising:
- applying a substrate to a cornea, wherein the substrate includes a surface coated with a copolymer comprising units -(A)- and -(B)- and corneal cells grown thereon with a population suitable for corneal therapy, in which the units A are derived from aminoalkyl (alkyl)acrylates;
- and the units B are derived from aryloxy, alkoxy or hydroxyalkyl (alkyl)acrylates, or (alkyl)acrylic acids.
A corneal bandage comprising:
- a polymeric material in which at least the surface comprises a copolymer comprising units -(A)- and -(B)- in which
- the units A are derived from aminoalkyl (alkyl)acrylates;
- and
- the units B are derived from aryloxy, alkoxy or hydroxyalkyl (alkyl)acrylates, or (alkyl)acrylic acids.
A corneal bandage, comprising:
- a bandage support with at least a surface layer of a copolymer comprising units -(A)- and -(B)- in which
- the units A are derived from aminoalkyl (alkyl)acrylates;
- and
- the units B are derived from aryloxy, alkoxy or hydroxyalkyl (alkyl)acrylates or (alkyl)acrylic acids
- to provide a surface having an affinity to corneal cells.
A method of preparing a corneal bandage for corneal therapy, comprising:
- providing a contact lens with at least a surface layer of a copolymer comprising units -(A)- and -(B)- in which
- the units A are derived from aminoalkyl (alkyl)acrylates;
- and
- the units B are derived from aryloxy, alkoxy or hydroxyalkyl (alkyl)acrylates or (alkyl)acrylic acids
- to provide a surface having an affinity to corneal cells, and
- growing corneal cells on the coated surface of the contact lens to obtain a corneal cell population suitable for corneal therapy.
Dependencies are inferred from the claim text.