Compositions and Methods for Promoting Patency of Vascular Grafts
AssigneeYale University
InventorsChristopher Breuer, Themis Kyriakides, Jason Roh
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Abstract
Methods for increasing the patency of biodegradable, synthetic vascular grafts are provided. The methods include administering one or more cytokines and/or chemokines that promote outward tissue remodeling of the vascular grafts and vascular neotissue formation. The disclosed methods do not require cell seeding of the vascular grafts, thus avoiding many problems associated with cell seeding. Biodegradable, polymeric vascular grafts which provide controlled release of cytokines and/or chemokines at the site of vascular graft implantation are also provided.
Claims22
A method for increasing the patency of a polymeric vascular graft comprising administering an effective amount of a cytokine or chemokine to promote the recruitment of host cells to the graft.
A polymeric vascular graft or conduit comprising an effective amount of a cytokine or chemokine to increase the recruitment of host cells to the graft relative to the graft without the cytokine or chemokine.
Dependencies are inferred from the claim text.