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AssigneesUniversidad De Chile, Oncobiomed
InventorsFlavio Andrés Salazar Onfray, Mercedes Natalia López Nitsche, Cristián Javier Pereda Ramos, Raquel Elvira Aguilera Insunza, Alejandro Felipe Escobar Álvarez
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The present invention relates to an ex vivo, fast and efficient process to obtain activated antigen-presenting cells that are useful for therapies against cancer and immune system-related diseases. At the same time, it is related to a cellular composition that contributes to stimulate the activated antigen-presenting cells to induce a specific immune response against tumors in patients with cancer or other pathologies involving immune responses.
A method to generate vaccines to stimulate the immune system, wherein the peripheral blood mononuclear cells—preferably monocytes—are induced to differentiate into APCs, preferably DCs, by the stimulation of said monocytes in an in-vitro culture within less than 3 days from the start-up of culture, using cytokines, growth factors and/or a mixture of lysate or extracts of tumor cells, then separate said APCs and mixed with adjuvant.
An extract of tumor cells, wherein it is manufactured by the mixture of at least two cell lines derived from tumors from metastatic tissue of patients with cancer;
A pharmaceutical composition, wherein said composition comprises APCs, DCs preferably, with qualities of mature DCs developed in vitro in less than 3 days with the capacity to induce the immune response;
Dependencies are inferred from the claim text.