Back to results
US 2010/0303864 A1Published application
Conserved and specific streptococcal genomes
OwnerHerve Tettelin, Vega Masignaniinventors
Life of this patent
Estimating the term…
Loading patent…
Loading patent…
OwnerHerve Tettelin, Vega Masignaniinventors
Estimating the term…
The invention relates to polynucleotides which are conserved or specific to one or more species of Streptococcus, Streptococcus species serotypes, and/or serotype isolates. In particular, the invention relates to polynucleotides from Streptococcus which are conserved or specific to one or more of the species of S. pneumoniae (“pneumococcus” or “S. pn.”), S. pyogenes (“group A streptococcus” or “GAS”), and S. agalactiae (“group B streptococcus” or “GBS”). The invention further relates to polynucleotides which are conserved or specific to one or more Streptococcal species serotypes, such as GBS serotypes Ia, Ib, II, III, IV, V, VI, VII, and VIII. The invention still further relates to polynucleotides which are conserved or specific to one or more clinical isolates of a Streptococcus species.
An immunogenic composition comprising a combination of GBS polypeptides, said combination consisting of two, three, four or five polypeptides, wherein each polypeptide is encoded by a GBS polynucleotide sequence which is homologous to a polynucleotide sequence of both GAS and Streptococcus pneumoniae.
An immunogenic composition comprising a combination of GBS polypeptides, said combination consisting of two, three, four or five polypeptides, wherein each polypeptide is encoded by a GBS polynucleotide sequence which is homologous to a polynucleotide sequence of GAS.
An immunogenic composition comprising a combination of GBS polypeptides, said combination consisting of two, three, four or five polypeptides, wherein each polypeptide is encoded by a GBS polynucleotide sequence which is homologous to a polynucleotide sequence of Streptococcus pneumoniae.
An immunogenic composition comprising a combination of GBS polypeptides, said combination consisting of two, three, four or five polypeptides, wherein each polypeptide is encoded by a GBS serotype polynucleotide sequence which is homologous to at least one other GBS serotype.
An immunogenic composition comprising a fusion protein, wherein said fusion protein comprises a first polypeptide sequence which is encoded by a GBS serotype polynucleotide which is conserved across one or more GBS serotypes.
A polynucleotide sequence, or a fragment comprising at least 10 contiguous polynucleotides, selected from SEQ ID NOS:1-122, 135-145, 157-167, 180-190, 202-210, 223-231, 241-251, 263-273, 285-295, 307-316, 327-337, 349-357, 367-375, 385-395, 407-417, 430-440, 452-457, 463-474, 486-496, 508-518, 530-540, 558-565, 574-584, 597-607, 619-629, 641-651, 663-673, 685-695, 707-717, 729-739, 752-762, 774-776, 780-790, 802-812, 823-833, 846-854, 864-874, 886-896, 908-918, 930-940, 952-954, 958-968, 980-990, 1002-1011, 1022-1032, 1044-1054, 1066-1076, 1088-1098, 1110-1120, 1132-1142, 1154-1156, 1182-1192, 1204-1214, 1226-1236, 1248-1258, 1271-1281, 1293-1301, 1311-1321 1333-1343.
A method of raising an immune response against S. pyogenes, S. agalactiae, and S. pneumoniae, comprising administering to a subject in need thereof an immunogenic composition comprising a combination of S. agalactiae polypeptides, wherein the combination consists of two, three, four, or five polypeptides, wherein each polypeptide is encoded by a S. agalactiae polynucleotide sequence which is homologous to a polynucleotide sequence of both S. pyogenes and S. pneumoniae.
Dependencies are inferred from the claim text.