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AssigneeTakeda Vaccines, Inc.
InventorsDan T. STINCHCOMB, Jorge E. OSORIO, Charalambos D. PARTIDOS, Joseph N. BREWOO
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Embodiments of the present invention report compositions and methods for vaccinating a subject against dengue viruses. In some embodiments, vaccine compositions may be administered by intradermal introduction. In certain embodiments, intradermal introduction in a subject of a vaccine against dengue virus may include one or more intradermal boosts after initial vaccination. Other embodiments include intradermal injection of a vaccine composition against dengue virus wherein the composition provides protection against two or more of DEN-1, DEN-2, DEN-3 and DEN-4.
A method for inducing protection in a subject against multiple dengue virus serotypes, comprising, administering a single dose vaccine against dengue virus to a subject by intradermal introduction, inducing protection in the subject against multiple dengue virus serotypes.
A composition for protecting a subject against a dengue virus serotype comprising, an intradermally (ID) administered single dose composition of predetermined ratio of at least 2 dengue virus serotypes.
A system for administering a dengue vaccine composition to a subject comprising, a vaccine composition against dengue virus and an apparatus capable of introducing intradermally the vaccine composition by a non-injectible method to a subject, administering the dengue vaccine composition to the subject.
A vaccine kit comprising;
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