Treatment of hyperproliferative disease with superantigens in combination with another anticancer agent

A method of reducing an antibody response to a tumor-targeted superantigen in a human, and enhancing a T cell response to a tumor-targeted superantigen in a human, comprising the steps of:

• reducing an antibody response to a tumor-targeted superantigen when administered to a human, which antibody response is reduced compared with the antibody response to a tumor-targeted superantigen when administered to a human without a chemotherapeutic agent, and enhancing a T cell response to a tumor-targeted superantigen when administered to a human, which T cell response is enhanced compared with the T cell response to a tumor-targeted superantigen when administered without a chemotherapeutic agent by administering non-localized via the circulatory system to the human a tumor-targeted superantigen comprising the modified superantigen SEA/E-120 conjugated with an antibody targeting moiety specific for a tumor-associated cell surface antigen, and not also administering intratumorally or intrathecally to said human said tumor-targeted superantigen, and administering a chemotherapeutic agent.

A method of reducing an antibody response to a tumor-targeted superantigen in a human, and increasing the anti-tumor effect of a chemotherapeutic agent in a human, comprising the steps of:

• reducing an antibody response to a tumor-targeted superantigen when administered to a human, which antibody response is reduced compared with the antibody response to a tumor-targeted superantigen when administered to a human without a chemotherapeutic agent, and increasing the anti-tumor effect of a chemotherapeutic agent when administered to a human, which anti-tumor effect is increased compared with the anti-tumor effect of a chemotherapeutic agent when administered to a human without a tumor-targeted superantigen by administering non-localized via the circulatory system to the human a tumor-targeted superantigen comprising the modified superantigen SEA/E-120 conjugated with an antibody targeting moiety specific for a tumor-associated cell surface antigen, and not also administering intratumorally or intrathecally to said human said tumor-targeted superantigen, and administering a chemotherapeutic agent.