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US 2010/0300971 A1Published application
Zwitterionic stationary phase as well as method for using and producing said phase
AssigneeSequant AB
InventorsWen Jiang, Knut Irgum
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AssigneeSequant AB
InventorsWen Jiang, Knut Irgum
Estimating the term…
The present invention relates to a zwitterionic stationary phase comprising a carrier and at least one zwitterionic ligand bound to said carrier, said phase being suitable for HPLC separation in Hydrophilic Interaction mode, wherein the positively charged part of said zwitterionic ligand is located at the end of the ligand, and the negatively charged part of said zwitterionic ligand is located between the positively charged part and the part of said zwitterionic ligand directly binding to said carrier, or a polymeric backbone attached to the carrier, wherein the intramolecular distance between the negatively charged part of the zwitterionic ligand preferably is at most 10 atoms long. The invention also provides methods for producing said zwitterionic stationary phase and method for using the phase in HPLC separations.
A zwitterionic stationary phase comprising a carrier and at least one zwitterionic ligand bound to said carrier, said phase being suitable for HPLC separation in Hydrophilic Interaction mode, wherein the positively charged part of said zwitterionic ligand is located at the end of the ligand, and the negatively charged part of said zwitterionic ligand is located between the positively charged part and the part of said zwitterionic ligand directly binding to said carrier, characterized in that the intramolecular distance between the negatively charged part of the zwitterionic ligand and the carrier is at most 10 atoms long.
A zwitterionic stationary phase comprising a carrier and at least one zwitterionic ligand bound to said carrier, said phase being suitable for HPLC separation in Hydrophilic Interaction mode, wherein the positively charged part of said zwitterionic ligand is located at the end of the ligand, and the negatively charged part of said zwitterionic ligand is located between the positively charged part and the part of said zwitterionic ligand directly binding to a polymeric backbone attached to the carrier, characterized in that the zwitterionic ligand has been bound to said carrier by graft polymerization of zwittionic monomers onto the surface of said carrier.
Dependencies are inferred from the claim text.