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AssigneesConsejo Nacional De Investigaciones Cietificas Y Tecnicas (Conicet), Universidad Nacional De Cordoba, Inis Biotec LLC
InventorsFernando José Irazoqui, Víctor Germán Sendra, Gustavo Alejandro Nores
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Modified Thomsen-Friedenreich disaccharide (TFD) immunogen, preparation procedure, compositions containing it, uses, and treatment methods. More specifically, the present invention refers to a immunogen obtained by modifying TFD, and comprising the general formula D-TFD-Lys(n)-C, wherein D is a hydrophobic terminal residue, TFD is disaccharide Galβ3GalNAcα; Lys(n) is a lysine connector, and n is an integer between 1 and 5, and C is a carrier. In a preferred embodiment, the modified invention immunogen comprises the general formula BzlαTFD-Lys5-KLHs, wherein Bzl is benzyl, TFD is disaccharide Galβ3GalNAcα; Lys5 is penta-lysine, and KLHs is succinilated Keyhole limpets hemocyanin.
A modified Thomsen-Friedenreich disaccharide (TFD) immunogen, characterized by comprising general formula D-TFD-Lys(n)-C, wherein
A composition to increase anti-tumoral immunity, characterized by comprising an effective amount of a modified Thomsen-Friedenreich disaccharide (TDF) immunogen of formula D-TFD-Lys(n)-C, wherein D is a hydrophobic terminal residue, TFD is disaccharide Galβ3GalNAcα, Lys(n) is a lysine connector, and n is an integer between 1 and 5, and C is a carrier;
A composition to inhibit adhesion of tumor cells and metastatic ability, characterized by comprising an effective amount of a modified Thomsen-Friedenreich disaccharide (TDF) of general formula D-TFD-Lys(n)-C, wherein D is a hydrophobic terminal residue, TFD is disaccharide Galβ3GalNAcα, Lys(n) is a lysine connector, and n is an integer between 1 and 5, and C is a carrier;
A method for the immunization of a mammal against antigen T, characterized by this method comprising the administration of an effective amount of a composition, wherein said composition comprises a modified Thomsen-Friedenreich disaccharide (TDF) immunogen of general formula D-TFD-Lys(n)-C, wherein D is a hydrophobic terminal residue, TFD is disaccharide Galβ3GalNAcα, Lys(n) is a lysine connector, and n is an integer between 1 and 5, and C is a carrier;
Dependencies are inferred from the claim text.