Process for forming solid oral dosage forms of angiotensin ii receptor antagonists

A method for producing granules comprising excipients wherein an angiotensin II receptor antagonist or a pharmaceutically acceptable salt thereof is added extra granularly, the method comprising:

• a) mixing a melt granulating agent and optional excipients to form a mixture;
• b) heating said mixture to a temperature greater than the melting point of said melt granulating agent to form a solid dispersion of said excipients in said melt granulating agent;
• c) cooling said solid dispersion to form granules;
• d) adding extra granular angiotensin II receptor antagonist or pharmaceutically acceptable salt thereof and optional excipients to said granules.

A method for producing granules comprising excipients wherein an angiotensin II receptor antagonist or a pharmaceutically acceptable salt thereof is added extra granularly, and wherein the angiotensin II receptor antagonist or a pharmaceutically acceptable salt thereof is the sole active ingredient, the method comprising:

• a) mixing a melt granulating agent and optional excipients to form a mixture;
• b) heating said mixture to a temperature greater than the melting point of said melt granulating agent to form a solid dispersion of said excipients in said melt granulating agent;
• c) cooling said solid dispersion to form granules;
• d) adding extra granular angiotensin II receptor antagonist or pharmaceutically acceptable salt thereof as the sole active ingredient and optional excipients to said granules.