Polyvalent chimeric rubella virus-based vaccines

A chimeric viral particle comprising a RV fusion gene, wherein said RV fusion gene comprises:

• a) a first nucleotide sequence encoding a RV that is devoid of RV E1 protein;
• and
• b) a second nucleotide sequence, linked in translation frame to the first nucleotide sequence, encoding a humoral immunogenic viral protein;
• wherein the chimeric viral particle is free of RV E1 protein-encoding gene.

An isolated expression vector comprising a RV fusion gene linked in translation frame to a promoter, wherein the RV fusion gene comprises:

• i) a first nucleotide sequence encoding a RV that is devoid of E1 gene;
• and
• ii) a second nucleotide sequence, linked in translation frame to the first nucleotide sequence, encoding a humoral immunogenic viral protein;
• wherein the expression vector is devoid of RV E1 protein-encoding nucleotide sequence.