Particles containing an active agent in the form of a co-precipitate
AssigneeEthypharm
InventorsGérard Cousin, Gaël Lamoureux
Life of this patent
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Abstract
The invention relates to particles containing an active agent in the form of a co-precipitate to a method for producing said particles and to pharmaceutical forms containing said particles.
Claims19
-16. (canceled)
A process for the preparation of a particle composed of a coprecipitate applied as a layer around a neutral hydrophilic carrier by spraying an organic solution over said neutral hydrophilic carrier,
- said organic solution comprising at least one active substance, one surface-active agent, and one hydrophilic polymer,
- wherein the spraying of the whole of the solution is carried out in at least two separate stages, each of these stages being followed systematically by a stage of milling the product obtained on conclusion of the preceding stag;
- wherein said process comprises the following stages:
- a) preparing said organic solution comprising the active substance, the hydrophilic polymer, and the surface-active agent,
- b) spraying a portion of the solution obtained in a) over the neutral hydrophilic carriers,
- c) milling the particles obtained in stage b),
- d) spraying the remaining amount of the organic solution over the particles milled in stage c), and
- e) final milling of the particles obtained in stage d).
A particle composed of a coprecipitate which is applied as a layer around a carrier and which comprises at least one active substance, one surface-active agent and one hydrophilic polymer, wherein it is capable of being obtained by spraying a solution comprising at least one active substance, one surface-active agent and one hydrophilic polymer, said spraying being carried out at least in two separate stages, said stages each being followed by a milling stage.
Dependencies are inferred from the claim text.