Therapeutic Use of the Encoding Sequence of the Carboxy-Terminal Domain of the Heavy Chain of the Tetanus Toxin
AssigneesUniversity of Zaragoza, The Autonomous University of Barcelona
InventorsMaria Moreno Igoa, Ana Cristina Calvo Royo, Maria Jesús Muñoz Gonzalvo, Maria Pilar Zaragoza Fernández, Rosario Osta Pinzolas, José Aguilera Avila
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Abstract
The present invention relates to the therapeutic use of the encoding sequence of the carboxy-terminal domain of the heavy chain of the tetanus toxin and of the polypeptide encoded by said sequence, preferably for the treatment of amyotrophic lateral sclerosis (ALS).
Claims24
A method for treating or ameliorating the symptoms of a neuronal degenerative disease of spinal, bulbar and motor cortex motor neurons, comprising the use of an isolated polynucleotide comprising the encoding sequence of the carboxy-terminal domain of the heavy subunit of the tetanus toxin (HcTeTx), its allelic variants, or functional fragments thereof.
A method for treating or ameliorating the symptoms of a neuronal degenerative disease of spinal, bulbar and motor cortex motor neurons, comprising the use of an isolated polypeptide comprising the carboxy-terminal domain of the heavy subunit of the tetanus toxin (HcTeTx), its allelic variants, or functional fragments thereof.
A method for treating or ameliorating the symptoms of a neuronal degenerative disease of spinal, bulbar and motor cortex motor neurons, comprising the use of an isolated polynucleotide consisting essentially of the encoding sequence of the carboxy-terminal domain of the heavy subunit of the tetanus toxin (HcTeTx), its allelic variants, or functional fragments thereof.
A method for treating or ameliorating the symptoms of a neuronal degenerative disease of spinal, bulbar and motor cortex motor neurons, comprising the use of an isolated polypeptide consisting essentially of the carboxy-terminal domain of the heavy subunit of tetanus toxin (HcTeTx), its allelic variants, or functional fragments thereof.
A method for the treatment of a neuronal disease, disorder, or condition of peripheral motor neurons comprising the use of an isolated polypeptide consisting essentially of the carboxy-terminal domain of the heavy subunit of tetanus toxin (HcTeTx), its allelic variants, or functional fragments thereof, or an isolated polynucleotide encoding essentially the carboxy-terminal domain of said heavy subunit of tetanus toxin, its allelic variants, or functional fragments thereof, wherein said polypeptide or polynucleotide has neuroprotectant activity.
Dependencies are inferred from the claim text.