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US 2010/0249561 A1Published application
LQG Artificial Pancreas Control System and Related Method
AssigneeUniversity of Virginia Patent Foundation
InventorsStephen D. Patek, Marc D. Breton
Life of this patent
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Abstract
The invention relates to a methods and systems for determining an insulin dosing recommendation. The invention employs Linear Quadratic methodology to determine the insulin dosing recommendation based on a patient's present physiological state, which is estimated by an adaptive filter methodology employing a dynamic model, which utilizes real-time measurements of blood glucose concentration.
Claims16
A method for determining an insulin dosing recommendation comprising:
- applying an adaptive observer scheme to estimate a present physiological state of a patient based on at least one measurement of blood glucose concentration in the patient, wherein the adaptive observer scheme models the present physiological state of the patient using a dynamic model;
- and
- applying the estimated physiological state to a Linear Quadratic regulator to determine an insulin dosing recommendation based on the present physiological state so estimated.
A method for determining an insulin dosing recommendation comprising:
- taking a measurement of blood glucose concentration in a patient at each of a plurality of actuation times;
- applying an adaptive filter scheme at each actuation time to generate an estimate of the patient's present physiological state based on the most recent measurement of blood glucose concentration;
- storing the estimate of the patient's present physiological state;
- and
- using Linear Quadratic methodology to determine an insulin dosing recommendation based on the estimate of the patient's present physiological state and based on any stored estimates of the patient's physiological state.
2 more elements
An artificial pancreas control system comprising:
- an observer, comprising a programmable computer controller programmed to receive real-time measurements of blood glucose concentration in a patient, and to apply an adaptive filter scheme to estimate a present physiological state of a patient based on the measurements of blood glucose concentration;
- and
- an LQ Regulator, comprising a second programmable computer controller programmed to receive the present physiological state estimation from the observer, and to use Linear Quadratic methodology to determine an insulin dosing recommendation based on the present physiological state.
Dependencies are inferred from the claim text.