C-(2-Phenyl-Cyclohexyl)-Methylamine Compounds for the Treatment of Anxiety Disorders
AssigneeGruenenthal GmbH
InventorsPetra Bloms-Funke, Werner Englberger, Hagen-Heinrich Hennies
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Abstract
Pharmaceutical formulations of [2-(3-methoxyphenyl)-cyclohexylmethyl]-dimethylamine and the metabolites thereof for treating anxiety, anxiety attacks and disorders as well as depression. Related methods of treating anxiety and anxiety attacks or depression are also provided, including methods of administering the active compounds as adjuvants to an antidepressant.
Claims9
A method for treating anxiety in a mammal, said method comprising administering to a mammal in need thereof a pharmaceutically effective amount of a pharmaceutical formulation comprising a C-(2-phenyl-cyclohexyl)-methylamine compound selected from the group consisting of:
- 3-(2-dimethylaminomethyl-cyclohexyl)-phenol,
- (1R,2R)-3-(2-dimethylaminomethyl-cyclohexyl)-phenol,
- [2-(3-methoxyphenyl)-cyclohexylmethyl]-dimethylamine,
- (1R,2R)-[2-(3-methoxyphenyl)-cyclohexylmethyl]-dimethylamine,
- sulfuric acid mono-[3-(2-dimethylaminomethyl-cyclohexyl)-phenyl]ester,
- sulfuric acid mono-(1R,2R)-[3-(2-dimethylaminomethyl-cyclohexyl)-phenyl]ester,
- 3-(2-methylaminomethyl-cyclohexyl)-phenol,
- (1R,2R)-3-(2-methylaminomethyl-cyclohexyl)-phenol,
- 3-(2-dimethylaminomethyl-cyclohexyl)-phenol, N-oxide,
- (1R,2R)-3-(2-dimethylaminomethyl-cyclohexyl)-phenol, N-oxide,
- 6-[3-(2-dimethylaminomethyl-cyclohexyl)-phenoxy]-3,4,5-trihydroxy-tetrahydropyran-2-carboxylic acid,
- 6-[(1R,2R)-3-(2-dimethylaminomethyl-cyclohexyl)-phenoxy]-3,4,5-trihydroxy-tetrahydropyran-2-carboxylic acid,
- 4-(2-dimethylaminomethyl-cyclohexyl)-catechol,
- (1R,2R)-4-(2-dimethylaminomethyl-cyclohexyl)-catechol,
- 3-(2-aminomethyl-cyclohexyl)-phenol,
- (1R,2R)-3-(2-aminomethyl-cyclohexyl)-phenol,
- C-[2-(3-methoxy-phenyl)-cyclohexyl]-methylamine,
- (1R,2R)—C-[2-(3-methoxy-phenyl)-cyclohexyl]-methylamine,
- [2-(3-methoxy-phenyl)-cyclohexylmethyl]-methylamine,
- (1R,2R)-[2-(3-methoxy-phenyl)-cyclohexylmethyl]-methylamine,
- [2-(3-methoxy-phenyl)-cyclohexylmethyl]-dimethylamine, N-oxide, and
- (1R,2R)-[2-(3-methoxy-phenyl)-cyclohexylmethyl]-dimethylamine, N-oxide,
- or a physiologically acceptable salt thereof.
A method for treating anxiety or depression in a mammal, said method comprising administering to a mammal in need thereof a pharmaceutically effective amount of a pharmaceutical formulation comprising a C-(2-phenyl-cyclohexyl)-methylamine compound selected from the group consisting of:
- 3-(2-dimethylaminomethyl-cyclohexyl)-phenol,
- (1R,2R)-3-(2-dimethylaminomethyl-cyclohexyl)-phenol,
- [2-(3-methoxyphenyl)-cyclohexylmethyl]-dimethylamine,
- (1R,2R)-[2-(3-methoxyphenyl)-cyclohexylmethyl]-dimethylamine,
- sulfuric acid mono-[3-(2-dimethylaminomethyl-cyclohexyl)-phenyl]ester,
- sulfuric acid mono-(1R,2R)-[3-(2-dimethylaminomethyl-cyclohexyl)-phenyl]ester,
- 3-(2-methylaminomethyl-cyclohexyl)-phenol,
- (1R,2R)-3-(2-methylaminomethyl-cyclohexyl)-phenol,
- 3-(2-dimethylaminomethyl-cyclohexyl)-phenol, N-oxide,
- (1R,2R)-3-(2-dimethylaminomethyl-cyclohexyl)-phenol, N-oxide,
- 6-[3-(2-dimethylaminomethyl-cyclohexyl)-phenoxy]-3,4,5-trihydroxy-tetrahydropyran-2-carboxylic acid,
- 6-[(1R,2R)-3-(2-dimethylaminomethyl-cyclohexyl)-phenoxy]-3,4,5-trihydroxy-tetrahydropyran-2-carboxylic acid,
- 4-(2-dimethylaminomethyl-cyclohexyl)-catechol,
- (1R,2R)-4-(2-dimethylaminomethyl-cyclohexyl)-catechol,
- 3-(2-aminomethyl-cyclohexyl)-phenol,
- (1R,2R)-3-(2-aminomethyl-cyclohexyl)-phenol,
- C-[2-(3-methoxy-phenyl)-cyclohexyl]-methylamine,
- (1R,2R)—C-[2-(3-methoxy-phenyl)-cyclohexyl]-methylamine,
- [2-(3-methoxy-phenyl)-cyclohexylmethyl]-methylamine,
- (1R,2R)-[2-(3-methoxy-phenyl)-cyclohexylmethyl]-methylamine,
- [2-(3-methoxy-phenyl)-cyclohexylmethyl]-dimethylamine, N-oxide, and
- (1R,2R)-[2-(3-methoxy-phenyl)-cyclohexylmethyl]-dimethylamine, N-oxide,
- or a physiologically acceptable salt thereof;
- wherein said C-(2-phenyl-cyclohexyl)-methylamine compound is administered as an adjuvant to at least one antidepressant.
Dependencies are inferred from the claim text.