Oligomeric Compounds And Compositions For Use In Modulation Of Pri-miRNAs
AssigneeRegulus Therapeutics Inc.
InventorsBridget Lollo, Ravi Jain
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Abstract
Compounds, compositions and methods are provided for modulating the levels expression, processing and function of pri-miRNAs. In particular, methods and compounds are provided for the modulation of the levels, expression, processing or function of polycistronic pri-miRNAs. The compositions comprise oligomeric compounds targeted to small non-coding RNAs and pri-miRNAs. Further provided are methods for selectively modulating pri-miRNA levels in a cell. Also provided are methods for identifying oligomeric compounds that result in increase pri-miRNA levels when contacted with a cell.
Claims7
An oligomeric compound 15 to 30 nucleobases in length targeted to a Drosha recognition region within the polycistronic pri-miRNA transcript from which miR-15a and miR-16-1 are derived.
Dependencies are inferred from the claim text.