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US 2010/0249169 A1Published application
Formulations for parenteral delivery of compounds and uses thereof
AssigneeWyeth
InventorsSyed M. Shah, Christian Ofslager, Mahdi B. Fawzi, Nataliya Bazhina
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Abstract
The present invention provides formulations that achieve effective delivery of methylnaltrexone compositions. The provided formulations are useful for preventing, treating delaying, diminishing or reducing the severity of side effects resulting from use of analgesic opioids.
Claims13
1-70. (canceled)
A pharmaceutical composition comprising:
- an aqueous solution of methylnaltrexone, or a pharmaceutically acceptable salt thereof, wherein the aqueous solution further comprises a calcium salt, a chelating agent, and a stabilizing agent that inhibits degradation of the methylnaltrexone in the solution into a compound of Formula (I),
- at room temperature,
- wherein the methylnaltrexone is methylnaltrexone bromide provided at a concentration of about 5 mg/mL to about 32 mg/mL.
Dependencies are inferred from the claim text.