Substituted pyrazolo-pyrimidine compounds

A compound having formula I or Ia:

• or a pharmaceutically acceptable salt or ester thereof, wherein:
• n is 1 or 2;
• R1 is H, unsubstituted or substituted C1-C6 alkyl, C(O)R11, C(O)OR11 or C(O)NR11R12;
• R11 and R12 are each independently H or -Q1-Ti;
• R2 is H or -Q2-T2;
• R3 is H or -Q3-T3;
• R4 is NRN1RN2, SRs or S(O)2RS;
• RN1 and RN2 are each independently H or -Q41-T41, or RN1 and RN2, together with the nitrogen atom they attach to, form a 5- or 6-member ring which optionally comprises 1-4 heteroatoms selected from N, O and S and is optionally substituted with 1-5 Rf;
• each Rf is independently H or -Q42-T42, or any two adjacent Rf, together with the atoms they attach to, form a 5- or 6-member ring which optionally comprises 1-4 heteroatoms selected from N, O and S and is optionally substituted;
• RS is H or unsubstituted or substituted C1-C6 alkyl;
• Q1, Q2, Q3, Q41 and Q42 are each independently a bond or unsubstituted or substituted C1-C6 alkyl linker;
• T1 is H, unsubstituted or substituted C1-C6 alkyl, unsubstituted or substituted C1-C6 alkoxy, unsubstituted or substituted C6-C10 aryl, unsubstituted or substituted C6-C10 aryloxy, unsubstituted or substituted heteroaryl comprising one or two 5- or 6-membered rings and 1-4 heteroatoms selected from N, O and S, unsubstituted or substituted C3-C10 carbocycle or unsubstituted or substituted heterocycle comprising one or two 5- or 6-membered rings and 1-4 heteroatoms selected from N, O and S;
• T2 is H, unsubstituted or substituted C1-C6 alkyl, unsubstituted or substituted C6-C10 aryl, unsubstituted or substituted heteroaryl comprising one or two 5- or 6-membered rings and 1-4 heteroatoms selected from N, O and S, unsubstituted or substituted C3-C10 carbocycle or unsubstituted or substituted heterocycle comprising one or two 5- or 6-membered rings and 1-4 heteroatoms selected from N, O and S;
• T3 is H, unsubstituted or substituted C1-C6 alkyl, unsubstituted or substituted C6-C10 aryl, unsubstituted or substituted heteroaryl comprising one or two 5- or 6-membered rings and 1-4 heteroatoms selected from N, O and S, unsubstituted or substituted C3-C10 carbocycle, unsubstituted or substituted heterocycle comprising one or two 5- or 6-membered rings and 1-4 heteroatoms selected from N, O and S, C(O)R31 or C(O)OR31;
• T41 is H, unsubstituted or substituted C1-C6 alkyl, unsubstituted or substituted C1-C6 alkoxy, unsubstituted or substituted amino, unsubstituted or substituted C1-C6 alkylamino, unsubstituted or substituted di-C1-C6 alkylamino, unsubstituted or substituted C6-C10 aryl, unsubstituted or substituted C6-C10 aryloxy, unsubstituted or substituted heteroaryl comprising one or two 5- or 6-membered rings and 1-4 heteroatoms selected from N, O and S, unsubstituted or substituted C3-C10 carbocycle or unsubstituted or substituted heterocycle comprising one or two 5- or 6-membered rings and 1-4 heteroatoms selected from N, O and S;
• T42 is H, unsubstituted or substituted C1-C6 alkyl, unsubstituted or substituted C6-C10 aryl, unsubstituted or substituted heteroaryl comprising one or two 5- or 6-membered rings and 1-4 heteroatoms selected from N, O and S, unsubstituted or substituted C3-C10 carbocycle, unsubstituted or substituted heterocycle comprising one or two 5- or 6-membered rings and 1-4 heteroatoms selected from N, O and S, C(O)R42 or C(O)OR42;
• R31 is H or unsubstituted or substituted C1-C6 alkyl;
• and
• R42 is H, unsubstituted or substituted C1-C6 alkyl, unsubstituted or substituted C6-C10 aryl, unsubstituted or substituted heteroaryl comprising one or two 5- or 6-membered rings and 1-4 heteroatoms selected from N, O and S, unsubstituted or substituted C3-C10 carbocycle or unsubstituted or substituted heterocycle comprising one or two 5- or 6-membered rings and 1-4 heteroatoms selected from N, O and S.