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US 2010/0249051 A1Published application
Bioactive Molecules from Co-Cultivation of Microbes
AssigneeMassachusetts Institute of Technology
InventorsAnthony J. Sinskey, Philip A. Lessard, Kazuhiko Kurosawa
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Abstract
Certain aspects of the invention relates to antibiotics, as well as pharmaceutically acceptable salts, pro-drugs and/or analogs thereof. Another aspect of the inventions relates to methods of use of said antibiotics.
Claims24
A pure and isolated compound represented by formula I or a pharmaceutically acceptable salt or pro-drug thereof:
- wherein, independently for each occurrence,
- X is O or S;
- Y is O, S or N(R7);
- R1 is hydrogen or an hydroxyl-protecting group, or two R1 taken together are a bridging hydroxyl-protecting group;
- R2 is hydrogen or an amino-protecting group;
- R3 is hydrogen or an amino-protecting group;
- R4 is hydrogen or an amino-protecting group;
- R5 is hydrogen, an amino-protecting group, alkyl, haloalkyl, or silyl;
- R6 is hydrogen or an amino-protecting group;
- R7 is hydrogen or an amino-protecting group;
- and
- the stereochemical configuration at any undefined stereocenter is R, S, or a mixture of these configurations.
9 more elements
A pure and isolated compound represented by
- or a pharmaceutically acceptable salt or pro-drug thereof.
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Dependencies are inferred from the claim text.