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US 2010/0249050 A1Published application
Epothilone glycoside and use thereof
AssigneeShandong University
InventorsYuezhong LI, Yuemao SHEN, Lin ZHAO, Chunhua LU
Life of this patent
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Abstract
An epothilone glycoside having a formula of and a pharmaceutical composition having the epothilone glycoside and a pharmaceutically acceptable excipient. The epothilone glycoside or the pharmaceutical composition having the epothilone glycoside can prevent or treat cancers such as liver cancer, lung cancer, and breast cancer.
Claims18
An epothilone glycoside having anticancer activity, said epothilone glycoside having a formula of
- wherein
- R1 + R2 = O, R3 = R4 = H, R5 = glycosyl
- epothilone glycoside A-1
- R1 + R2 = O, R3 = R5 = H, R4 = glycosyl
- epothilone glycoside A-2
- R1 + R2 = O, R3 = CH3, R4 = H, R5 = glycosyl
- epothilone glycoside B-1
- R1 + R2 = O, R3 = CH3, R5 = H, R4 = glycosyl
- epothilone glycoside B-2,
- or
- wherein
- R4 = H, R5 = glycosyl
- epothilone glycoside C-1
- R4 = glycosyl, R5 = H
- epothilone glycoside C-2.
12 more elements
Dependencies are inferred from the claim text.