Crf conjugates with extended half-lives
OwnerWilliam Henryinventor
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Abstract
The present invention relates to conjugates of CRF that have been modified to include a moiety that protects CRF from degradation and prolongs the half-life of CRF. The CRF conjugates of the invention have an increased half-life which results in a dose-sparing effect and less frequent administration
Claims23
A CRF conjugate comprising CRF, wherein the CRF is chemically modified with polyethylene glycol.
(canceled)
(canceled)
A pharmaceutical composition comprising CRF chemically modified with polyethylene glycol and a pharmaceutically acceptable diluent, adjuvant or carrier.
A method of treating edema in a patient comprising administering to the patient a composition comprising CRF chemically modified with polyethylene glycol and a pharmaceutically acceptable diluent, adjuvant or carrier.
-32. (canceled)
Dependencies are inferred from the claim text.