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US 2010/0248269 A1Published application
Detection of fibrin and fibrinogen degradation products and associated methods of production and use for the detection and monitoring of cancer
AssigneeNew York Blood Center, Inc.
InventorAndrea Small-Howard
Life of this patent
Estimating the term…
Abstract
Disclosed herein are methods, systems and kits for the detection of, or monitoring the progression of, cancer by simultaneously detecting the presence of six fibrin and fibrinogen degradation products (FDP) in a biological sample in a single assay system.
Claims15
A method for detecting cancer in a subject, said method comprising the steps of:
- obtaining a biological sample from said subject;
- reacting said biological sample with an antibody preparation which binds at least three antigens associated with fibrin and fibrinogen degradation products (FDP) to form antibody-FDP complexes wherein said three FDP-associated antigens are fragment D, fragment E and D-dimer;
- detecting said antibody-FDP complexes;
- and
- diagnosing cancer in said subject.
2 more elements
A method of monitoring cancer in a patient comprising:
- (a) obtaining a first biological sample from said subject, said first sample collected at a first sampling time point;
- (b) obtaining a second biological sample from said subject, said second sample collected after said first sampling time point at a second sampling time point;
- (c) reacting said biological samples with an antibody preparation which binds at least three antigens associated with FDP to form antibody-FDP complexes wherein said three FDP-associated antigens are fragment D, fragment E and D-dimer;
- (d) detecting said antibody-FDP complexes;
- and
- (e) determining the ratio of the level of FDP in said second biological sample to the level of FDP in said first biological sample;
- (f) determining that cancer has progressed;
- and
- optionally repeating steps (a)-(e) with additional biological samples taken at time points after said first and said second time points.
6 more elements
A kit for detecting cancer in a subject, said kit comprising:
- an antibody preparation which binds to at least three antigens associated with FDP wherein said three FDP-associated antigens are fragment D, fragment E and D-dimer;
- a detection system;
- and
- instructions for measuring said FDP and correlating the presence of said FDP with cancer.
1 more element
Dependencies are inferred from the claim text.