Arsenic trioxide medical elution scaffold
AssigneeBeijing Amsino Medical Co., Ltd.
InventorsJunbo Ge, Xiaoyi Ma
Life of this patent
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Abstract
An arsenic trioxide medical elution scaffold and preparation method thereof, wherein the arsenic trioxide medical elution scaffold comprises scaffold, polymer coating covering the scaffold and arsenic trioxide loaded in the polymer coating which is in the form of single particle or particle conglomeration island. Animal experiments testify that the medical release of the arsenic trioxide medical elution scaffold is suitably uniform, and can be controlled to meet clinic requirement.
Claims22
An arsenic trioxide medical elution scaffold comprising a scaffold, a polymer coating covering the scaffold and arsenic trioxide loaded in the polymer coating, characterized in that the arsenic trioxide is loaded in the polymer coating as single particles or as isolated and scattered conglomerated particles.
A method for preparing an arsenic trioxide medical elution scaffold, the method comprising:
- (1) dissolving a polymer in an organic solvent and dissolving arsenic trioxide in water, then adding a surfactant thereto respectively;
- mixing these two and emulsifying to obtain an emulsion, then spraying the emulsion onto a scaffold to obtain a medical coating after evaporation of the solvent;
- (2) leveling the polymer on the surface of the emulsion particles with a liquid solvent or a gas solvent, or spraying a new coating on the scaffold, then drying to obtain the arsenic trioxide medical elution scaffold.
A method for preparing an arsenic trioxide medical elution scaffold, the method comprising:
- dissolving the polymer in an organic solvent;
- suspending arsenic trioxide particles in alcohol, adding a surfactant thereto, adding the suspension to the polymer solution and stirring to form a polymer thin film on the surface of As2O3 and form an emulsion, and then spraying the emulsion on the surface of the scaffold and drying to obtain the arsenic trioxide elution scaffold.
A method for preparing an arsenic trioxide medical elution scaffold, the method comprising:
- spraying an arsenic trioxide aqueous solution and an organic solvent containing a polymer onto a scaffold respectively several times with one layer of the polymer solution on one layer of the arsenic trioxide aqueous solution coating, and leveling the polymer with a liquid solvent or a gas solvent each time after coating the polymer solution to enwrap a layer of the polymer on the surface of the arsenic trioxide particles, then drying in vacuum to obtain the arsenic trioxide medical elution scaffold.
A method for preparing an arsenic trioxide medical elution scaffold, the method comprising:
- (1) drilling micropores on the surface of a scaffold by a laser method, mixing arsenic trioxide particles and an organic solvent containing a polymer to suspend the arsenic trioxide particles in the organic solvent containing the polymer, then coating the polymer solution comprising medicine into the micropores in the scaffold.
Dependencies are inferred from the claim text.