CHIMERIC NEWCASTLE DISEASE VIRUS VLPs
OwnerKutub Mahmood, Gale Smith +1inventors
InventorsKutub Mahmood, Gale Smith, Peter Pushko
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Abstract
The present invention discloses and claims chimeric virus like particles (VLPs) that express and/or contains Newcastle disease matrix protein. The invention includes vector constructs comprising said proteins, cells comprising said constructs, formulations and vaccines comprising chimeric VLPs of the inventions. The invention also includes methods of making and administrating chimeric VLPs to vertebrates, including methods of inducing immunity to infections.
Claims21
A chimeric virus like particle (VLP) comprising a Newcastle Disease Virus (NDV) core protein (M) and at least one protein from a different infectious agent, wherein the VLP is noninfectious and does not comprise genetic material encoding for the proteins;
- and wherein the at least one protein is fused to a NDV protein or fragment thereof that associates with the VLP.
-91. (canceled)
A method of inducing an immune response in a vertebrate comprising administering to said vertebrate chimeric VLPs comprising a Newcastle Disease Virus (NDV) viral core protein (M) and at least one protein from a different infectious agent, wherein the VLP is noninfectious and does not comprise genetic material encoding for the proteins;
- and wherein the at least one protein is fused to a NDV protein or fragment thereof that associates with the VLP.
Dependencies are inferred from the claim text.