West nile virus vaccine, and method for production thereof
AssigneesJapan AS Represented By Director-General of National Institute of Infectious Diseases, The Research Foundation for Microbial Diseases of Osaka University
InventorsAsato Kojima, Hidehiro Takahashi, Toyokazu Ishikawa
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Abstract
The present invention provides virus-like particles (VLP) highly secreting or producing signal peptide obtained by altering a signal sequence derived from West Nile virus (WNV), the signal peptide, a WNV VLP secretion expression vector containing a nucleic acid encoding prM protein and E protein, a WNP VLP highly secreting or producing animal cell line harboring the vector, a WNV vaccine containing WNV VLP obtained by the cell line as an active ingredient, and a WNV DNA vaccine containing the VLP secretion expression vector as an active ingredient.
Claims10
A signal peptide comprising an amino acid sequence the same or substantially the same as the amino acid sequence of the following (a) or (b)
- (a) the amino acid sequence shown by SEQ ID NO:
- 1
- (b) a partial amino acid sequence of the amino acid sequence of said (a), comprising at least the amino acid sequence shown by amino acid NOs 11-25.
Dependencies are inferred from the claim text.