Opsonic monoclonal and chimeric antibodies specific for lipoteichoic acid of gram positive bacteria
AssigneesThe Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Altor BioScience Corporation
InventorsGERALD WALTER FISCHER, RICHARD F. SCHUMAN, HING WONG, JEFFREY R. STINSON
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Abstract
The present invention encompasses monoclonal antibodies that bind to lipoteichoic acid (LTA) of Gram positive bacteria. The antibodies also bind to whole bacteria and enhance phagocytosis and killing of the bacteria in vitro. The invention also provides antibodies having human sequences (chimeric, humanized and human antibodies). The invention also sets forth the variable regions of three antibodies within the invention and presents the striking homology between them.
Claims27
An isolated monoclonal antibody, or antigen-binding fragment thereof, that binds to lipoteichoic acid (LTA) of Gram positive bacteria, wherein at least a portion of the antibody variable region is obtained from a phage display library comprising human antibody sequences or is obtained from a cell comprising a human antibody sequence.
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An isolated human monoclonal antibody or fragment thereof that specifically binds to lipoteichoic acid (LTA) of Gram positive bacteria.
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-28. (canceled)
A composition comprising an isolated monoclonal antibody or antigen-binding fragment thereof, and a pharmaceutically acceptable carrier, wherein the antibody specifically binds to lipoteichoic acid (LTA) of Gram positive bacteria and comprises a portion of a human antibody sequence.
Dependencies are inferred from the claim text.