Treatment and prevention of neurodegenerative diseases
AssigneeOryzon Genomics, S.A.
InventorsTamara Maes, Marta Barrachina Castillo, Isidro Ferrer Abizanda
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Abstract
The treatment and prevention of neurodegenerative diseases by repression of the transcriptional complex that silences the promoter of the UCHL1 gene.
Claims20
A method of treating or preventing a neurodegenerative disease in a patient suffering from such a condition which comprises identifying a patient in need of prevention or treatment and administering to said patient a therapeutically effective amount of an agent that represses the transcriptional complex that represses the promoter of the UCHL1 gene.
A method for identifying a compound that represses the transcriptional complex that represses the expression of the UCHL1 promoter comprising providing a compound which is a small molecule inhibitor of a protein chosen from REST, sin3a, HDAC1,HDAC2, MeCP2, AOF2, RCOR1, JARID1C, BAF57, BAF170 and BRG1 and testing for the ability of said compound to repress the transcriptional complex that represses the promoter of the UCHL1 gene.
Dependencies are inferred from the claim text.