Compositions and methods for treating anthrax lethality
AssigneeUniversity of Virginia Patent Foundation
InventorsEdward N. Martin, JR., W. Michael Scheld
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Abstract
The present invention provides compositions and methods for preventing and inhibiting anthrax lethality. The present invention relates to protect a subject from anthrax lethality by presensitizing a subject prior to anthrax infection. The present invention further provides compositions and methods for enhancing the innate system to inhibit anthrax-associated lethality. The invention further provides compositions and methods for preventing and inhibiting lethality due to infection regulated via a TNF-α pathway.
Claims31
A method of inhibiting anthrax-associated lethality in a subject in need thereof, said method comprising administering to said subject a pharmaceutical composition comprising an effective amount of at least one TNF-α-inhibiting compound and a pharmaceutically-acceptable carrier.
A method of enhancing survival against a pathogen or toxin in a subject in need thereof, said method comprising administering to said subject a pharmaceutical composition comprising an effective amount of an enhancer of the innate immune system, thereby enhancing survival of said subject.
A method of protecting a subject from anthrax-associated lethality, said method comprising presensitizing said subject by administering a pharmaceutical composition comprising an effective amount of at least one presensitizing agent prior to infection of said subject with anthrax.
A kit for treating anthrax-associated lethality in a subject in need thereof, said kit comprising a pharmaceutical composition comprising an effective amount of at least one TNF-α inhibiting compound packaged in one or more unit dosages, an instructional material for the use thereof, an applicator, and optionally one or more of at least one enhancer of the innate immune system packaged in one or more unit dosages, at least one compound to presensitize the subject to the lethal toxin effects of anthrax packaged in one or more unit dosages, and at least one antibiotic packaged in one or more unit dosages.
Dependencies are inferred from the claim text.