Polypeptides, antibody variable domains and antagonists
AssigneeDomantis Limited
InventorsMichael Steward, Malgorzata Pupecka, Ian Tomlinson, Carolyn Enever, Laurent S. Jespers, Thil Dinuk Batuwangala
Life of this patent
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Abstract
The invention relates to anti-VEGF polypeptides and antibody single variable domains (dAbs) that are resistant to degradation by a protease, as well as antagonists comprising these. The polypeptides, dAbs and antagonists are useful for pulmonary administration, oral administration, delivery to the lung and delivery to the GI tract of a patient, as well as for treating cancer and inflammatory disease, such as arthritis.
Claims31
An anti-VEGF immunoglobulin single variable domain comprising an amino acid sequence that is at least 97% identical to the amino acid sequence of DOM 15-26-593 (shown in FIG. 5), and which further comprises a domain of an antibody constant region.
An anti-VEGF immunoglobulin single variable domain comprising an amino acid sequence that is identical to the amino acid sequence of DOM15-26-593 (shown in FIG. 5), and which further comprises a domain of an antibody constant region.
An anti-VEGF immunoglobulin single variable domain encoded by a nucleotide sequence that is at least 80% identical to a sequence selected from the nucleic acid sequence of DOM15-26-593 (shown in FIG. 20c), and which variable domain further comprises a domain of an antibody constant region.
An anti-VEGF immunoglobulin single variable domain encoded by a sequence that is identical to the nucleic acid sequence of DOM 15-26-593 (shown in FIG. 20c), and which further comprises a domain of an antibody constant region.
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An anti-VEGF antagonist that competes with DOM 15-26-593 for binding to VEGF, and which further comprises a domain of an antibody constant region.
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An anti-VEGF immunoglobulin single variable domain, which is present as a fusion with an Fc and which has an amino acid sequence identical to the amino acid sequence of DOM15-26-593-Fc fusion (shown in FIG. 52a).
An anti-VEGF immunoglobulin single variable domain which is present as a fusion with an Fc and which has an amino acid sequence which is 97% to the amino acid sequence of DOM 15-26-593-Fc fusion (shown in FIG. 52a).
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Dependencies are inferred from the claim text.