Pericellular Collagenase Directs the 3-Dimensional Development of White Adipose Tissue
AssigneeThe Regents of the University of Michigan
InventorsStephen Weiss, Tae-Hwa Chun
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Abstract
Methods are provided for regulating fat storage, carbohydrate metabolism and fatty acid synthesis using modulators of membrane type matrix metalloproteinase 1 (MT1-MMP).
Claims17
A methods of regulating fat storage comprising the step of administering a modulator of membrane-tethered metalloproteinase 1 (MT1-MMP) in an amount effective to modulate MT1-MMP activity.
A method of increasing fat storage comprising the step of administering an amount of membrane-tethered metalloproteinase 1 (MT1-MMP) in an amount effective to increase fat storage.
A method of regulating carbohydrate metabolism comprising the step of administering a modulator of membrane-tethered metalloproteinase 1 (MT1-MMP) in an amount effective to modulate carbohydrate metabolism.
A method of increasing carbohydrate metabolism comprising the step of administering an amount of membrane-tethered metalloproteinase 1 (MT1-MMP) in an amount effective to increase carbohydrate metabolism.
A method of regulating fatty acid synthesis comprising the step of administering a modulator of membrane-tethered metalloproteinase 1 (MT1-MMP) in an amount effective to modulate fatty acid synthesis.
A method of increasing fatty acid synthesis comprising the step of administering an amount of membrane-tethered metalloproteinase 1 (MT1-MMP) in an amount effective to increase fatty acid synthesis.
A method of regulating fat storage comprising the step of administering a modulator of a membrane-tethered metalloproteinase 1 (MT1-MMP) downstream pathway component in an amount effective to modulate activity of said component.
Dependencies are inferred from the claim text.