Tumor/b-cell hybrid cells and uses thereof
OwnerGustavo Antonio MOVIGLIAinventor
Life of this patent
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Abstract
The present invention is directed to methods and compositions for slowing or inhibiting the growth of tumors and decreasing the size of existing tumors. The compositions include dendritic cells contacted with tumor/B-cell hybrid cells and various T-cells contacted with tumor/B-cell hybrid cells (TBH cells). The present invention further encompasses methods of generating such compositions and methods of use of such compositions.
Claims19
1-9. (canceled)
A composition comprising a plurality of cells including isolated human CD8+ cells and tumor/B-cell hybrid cells.
A composition comprising isolated human CD8+ cells wherein the CD8+ cells have been contacted with tumor/B-cell hybrid cells for a sufficient time to stimulate proliferation CD8+ cells that recognize tumor antigens.
A method of generating CD8+ cells contacted with tumor/B-cell hybrid cells comprising:
- a) providing isolated human CD8+ cells;
- b) contacting the CD8+ cells with tumor/B-cell hybrid cells for a sufficient time to stimulate proliferation CD8+ cells that recognize tumor antigens.
24-66. (canceled)
A method of slowing or inhibiting cancer growth comprising administering to an individual in need thereof an effective amount of human CD8+ cells contacted in vitro with TBH cells.
68-77. (canceled)
Dependencies are inferred from the claim text.