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AssigneesHuman Matrix Sciences, LLC, The Hospital for Sick Children
InventorsThomas Mitts, Felipe Jimenez, Aleksander Hinek, Severa Bunda
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The present invention describes therapeutic compositions comprising one or more minerals, including trivalent iron, divalent manganese and salts thereof, suitable in facilitating synthesis and deposition of connective tissue matrix, particularly rich of elastin and collagen, and mitogenic potential in human dermal fibroblasts. It also describes the phenomenon in which stimulation of elastogenesis by arterial SMC associates with a net decrease in proliferation of these cell types. The present invention also describes methods of treatment of human skin fibroblasts and arterial smooth muscle cells. The therapeutic compositions of the present invention comprise one or more of trivalent iron or divalent manganese or salts thereof and may be combined with an elastic tissue digest.
A therapeutic composition comprising one or more of a divalent manganese based compound or trivalent iron based compound.
A therapeutic skin care product comprising a therapeutically effective amount of a trivalent iron based compound or divalent manganese based compound.
A method of treating connective tissue comprising administering to a site in need thereof on a mammal an effective amount of a therapeutic composition comprising a divalent manganese based compound.
A method of stimulating the production of elastin comprising administering to a site in need thereof on a mammal an effective amount of a therapeutic composition comprising a trivalent iron based compound or divalent manganese based compound.
A method of stimulating the production of collagen comprising administering to a site in need thereof on a mammal an effective amount of a therapeutic composition comprising a divalent manganese based compound or trivalent iron based compound.
A method of improving the appearance of a tissue site comprising scar tissue, visible lines or wrinkles comprising administering to a site in need thereof on a mammal an effective amount of a therapeutic composition comprising a divalent manganese based compound or trivalent iron based compound.
A method of regulating elastin gene expression comprising administering to a site in need thereof on a mammal an effective amount of a therapeutic composition comprising a trivalent iron based compound or divalent manganese based compound.
A composition comprising desferrioxamine useful in treating skin damage in patients with iron overload.
A method of treating skin damage comprising administering a therapeutically effective amount of desferrioxamine to a subject with iron overload.
Dependencies are inferred from the claim text.