Animal model simulating neurologic disease

A method for inducing a neurologic disease in a non-human animal, comprising:

• perfusing the non-human animal with a pharmacologically effective amount of a combination of an Aβ compound, at least one pro-oxidative compound, and at least one anti-oxidant inhibitor.

The method of claim 27, wherein the pro-inflammatory compound is selected from the group consisting of TNF-α, IL-6, and IL-1b.

A method of screening for an agent that ameliorates symptoms of a neurologic disease, said method comprising:

• comparing performance on memory and learning tests of a first non-human animal contacted with the agent with that of a second non-human animal not contacted with the agent, wherein the first and said second non-human animals have been co-infused with a pharmacologically effective amount of Aβ, at least one pro-oxidative compound, and at least one anti-oxidant inhibitor wherein the co-infusion produces impaired performance on the memory and learning tests and abnormal neuropathology in a brain of the first and second non-human animals, wherein the impaired performance and the abnormal neuropathology are in comparison with control non-human animals, whereby an agent which ameliorates the symptoms is identified by superior performance of said first non-human animal in comparison with the second non-human animal on the memory and learning tests.

A method for screening for an agent useful for treating a neurologic disease, said method comprising:

• comparing performance on memory and learning tests of a first non-human animal contacted with the agent with that of a second non-human animal not contacted with the agent, wherein the first and said second non-human animals have been co-infused with a pharmacologically effective amount of Aβ and at least one pro-oxidative compound, and at least one anti-oxidant inhibitor, wherein the co-infusion produces impaired performance on the memory and learning tests and abnormal neuropathology in a brain of the first and second non-human animals, wherein the impaired performance and the abnormal neuropathology are compared with control non-human animals;
• and comparing neuropathology in the brain of the first and the second non-human animal when said first non-human animal exhibits superior performance on the memory and learning tests compared with the second non-human animal, whereby an agent which is useful for treating a neurologic disease is identified by a decrease in neuropathologic findings in the first non-human animal in comparison with the second non-human animal.