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US 2010/0169023 A1Published application
Computational methods and systems for suggesting modulators of CYP450 as treatment options
AssigneeSearete LLC, a limited liability corporation of the State of Delaware
InventorsMahalaxmi Gita Bangera, Roderick A. Hyde, Elizabeth A. Sweeney, Lowell L. Wood, JR.
Life of this patent
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Abstract
Computational methods and systems are described which accept input, identify one or more CYP450-family enzymes, identify one or more modulators of the CYP450-family enzymes, and communicate treatments to at least one system user, wherein the treatments include one or more of the identified at least one modulator.
Claims68
A method comprising:
- accepting input that specifies an individual;
- accepting input that identifies a drug therapy associated with the individual;
- identifying at least one first CYP450-family enzyme that influences metabolism of the drug therapy associated with the individual;
- identifying at least one second CYP450-family enzyme that influences metabolism of the drug therapy associated with the individual;
- identifying at least one modulator of one or more of the at least one first CYP450-family enzyme;
- identifying at least one modulator of one or more of the at least one second CYP450-family enzyme;
- and
- invoking circuitry for communicating one or more treatment to a system user, wherein the treatment includes one or more of the identified at least one modulator of one or more of the at least one first CYP450-family enzyme and one or more of the identified at least one modulator of one or more of the at least one second CYP450-family enzyme.
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A system, comprising:
- circuitry for accepting input that specifies an individual;
- circuitry for accepting input that identifies a drug therapy associated with the individual;
- circuitry for identifying at least one first CYP450-family enzyme that influences metabolism of the drug therapy associated with the individual;
- circuitry for identifying at least one second CYP450-family enzyme that influences metabolism of the drug therapy associated with the individual;
- circuitry for identifying at least one modulator of one or more of the at least one first CYP450-family enzyme;
- circuitry for identifying at least one modulator of one or more of the at least one second CYP450-family enzyme;
- and
- circuitry for communicating one or more treatment to a system user, wherein the treatment includes one or more of the identified at least one modulator of one or more of the at least one first CYP450-family enzyme and one or more of the identified at least one modulator of one or more of the at least one second CYP450-family enzyme.
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A method comprising:
- accepting input that specifies an individual;
- accepting input that identifies a first drug therapy associated with the individual;
- accepting input that identifies a second drug therapy associated with the individual;
- identifying at least one CYP450-family enzyme that influences metabolism of both the first drug therapy and the second drug therapy;
- identifying at least one modulator of one or more of the at least one CYP450-family enzyme;
- and
- invoking circuitry for communicating one or more treatment to a system user, wherein the one or more treatment includes one or more of the identified at least one modulator.
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A system comprising:
- circuitry for accepting input that specifies an individual;
- circuitry for accepting input that identifies a first drug therapy associated with the individual;
- circuitry for accepting input that identifies a second drug therapy associated with the individual;
- circuitry for identifying at least one CYP450-family enzyme that influences metabolism of both the first drug therapy and the second drug therapy;
- circuitry for identifying at least one modulator of one or more of the at least one CYP450-family enzyme;
- and
- circuitry for communicating one or more treatment to a system user, wherein the one or more treatment includes one or more of the at least one modulator.
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A system, comprising:
- at least one computer program for use with at least one computer system and wherein the computer program includes a plurality of instructions including but not limited to:
- one or more instructions for accepting input that specifies an individual;
- one or more instructions for accepting input that identifies a drug therapy associated with the individual;
- one or more instructions for identifying at least one first CYP450-family enzyme that influences metabolism of the drug therapy associated with the individual;
- one or more instructions for identifying at least one second CYP450-family enzyme that influences metabolism of the drug therapy associated with the individual;
- one or more instructions for identifying at least one modulator of one or more of the at least one first CYP450-family enzyme;
- one or more instructions for identifying at least one modulator of one or more of the at least one second CYP450-family enzyme;
- and
- one or more instructions for communicating one or more treatment to a system user, wherein the treatment includes one or more of the identified at least one modulator of one or more of the at least one first CYP450-family enzyme and one or more of the identified at least one modulator of one or more of the at least one second CYP450-family enzyme.
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A system comprising:
- at least one computer program for use with at least one computer system and wherein the computer program includes a plurality of instructions including but not limited to:
- one or more instructions for accepting input that specifies an individual;
- one or more instructions for accepting input that identifies a first drug therapy associated with the individual;
- one or more instructions for accepting input that identifies a second drug therapy associated with the individual;
- one or more instructions for identifying at least one CYP450-family enzyme that influences metabolism of both the first drug therapy and the second drug therapy;
- one or more instructions for identifying at least one modulator of one or more of the at least one CYP450-family enzyme;
- and
- one or more instructions for communicating one or more treatment to a system user, wherein the one or more treatment includes one or more of the at least one modulator.
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Dependencies are inferred from the claim text.