Bioactive composites of polymer and glass and method for making same
OwnerTheodore D. Clineff, Marissa M. Darmoc +3inventors
InventorsTheodore D. Clineff, Marissa M. Darmoc, Matthew B. Havener, James P. Murphy, Zachary S. Szczerbinski
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Abstract
The present invention generally relates to bioactive composites of polymer and glass and, more particularly, to bioactive implants. The present invention also relates to methods of manufacturing bioactive composites. The bioactive composite finds utility in a variety of load-bearing clinical applications including spine, orthopaedic and dental procedures.
Claims97
A bioactive composite comprising a biocompatible polymer and a bioactive glass, wherein the biocompatible polymer has a particle size range from greater than 400 μm to 4,000 μm prior to formation of said bioactive composite.
A bioactive composite, comprising a PEEK and Combeite, wherein the PEEK has a particle size range from greater than 400 μm to 4,000 μm prior to formation of said bioactive composite, wherein the PEEK has a molecular weight from 70,000 to 100,000 Mn, wherein the PEEK comprises from 70% to 80% by weight of the composite composition, wherein the Combeite has a particle size range from 1 μm to 500 μm, and wherein the Combeite comprises from 20% to 30% by weight of the composite composition.
A method of preparing a bioactive composite, the method comprising the steps of:
- a) adding in a solid state a biocompatible polymer and a bioactive glass to an extruder to form an extrudable material;
- and
- b) applying energy to the extrudable material to at least the melting temperature of the biocompatible polymer to melt mix the biocompatible polymer and bioactive glass;
- and
- c) extruding a bioactive composite.
A method of preparing a bioactive composite, the method comprising the steps of:
- a) adding in a solid state PEEK and Combeite to a screw extruder to form an extrudable material;
- wherein the PEEK has a particle size range from greater than 400 μm to 4,000 μm, and wherein the PEEK has a molecular weight from 70,000 to 110,000 Mn, and wherein the PEEK comprises from 70% to 85% by weight of the extrudable material, and wherein the Combeite has a particle size range from 1 μm to 500 μm, and wherein the Combeite comprises from 15% to 30% by weight of the extrudable material;
- and
- b) applying heat to the extrudable material to at least the melting temperature of the PEEK to melt mix the PEEK and Combeite;
- and
- c) extruding a bioactive composite.
A method for fusing two adjacent vertebral bodies of the spine comprising the steps of:
- a) surgically exposing two vertebral bodies;
- b) removing disc material between the two vertebral bodies;
- and
- c) inserting a spinal implant between the two vertebral bodies in the disc space so that a top surface of the implant contacts a first of the two vertebral bodies and a bottom surface of the implant contacts a second of the two vertebral bodies, wherein the spinal implant comprises a biocompatible polymer and a bioactive glass.
A method for repairing a defect in bone comprising the step of administering to the bone an implant comprising a biocompatible polymer and a bioactive glass, wherein the biocompatible polymer has a particle size range from greater than about 400 um to 4000 um prior to formation of said implant
A method for repairing a damaged bone or tooth comprising placing in the bone or jaw an implant comprising a biocompatible polymer and a bioactive glass, wherein the biocompatible polymer has a particle size range from greater than about 400 um to 4000 um prior to formation of said implant.
A method of inserting a dental implant into a bone structure, comprising the steps of:
- a) dissecting a tissue layer overlying the bone structure to provide a flap of tissue and expose a portion of the bone structure;
- b) forming a cavity in the exposed portion of the bone structure;
- inserting a shaped implant into the cavity, wherein the shaped implant is comprised of a biocompatible polymer and a bioactive glass, wherein the biocompatible polymer has a particle size range from greater than about 400 um to 4000 um prior to formation of said dental implant.
A method for replacing a diseased or dysfunctional hip joint comprising the steps of:
- resecting a femoral head to expose a femoral intramedullary canal;
- and inserting a bioactive hip stem into the intramedullary canal for fixation thereto, wherein the hip stem is comprised of a biocompatible polymer and a bioactive glass, wherein the biocompatible polymer has a particle size range from greater than about 400 um to 4000 um prior to formation of said bioactive hip stern.
An injection moldable composition comprising a bioactive composite pellet, wherein the pellet is comprised of a polymer and bioactive glass, the polymer comprising from 50% to 85% by weight of the composition and the bioactive glass comprising from 15% to 50% by weight of the composition.
A method of enhancing bone bonding properties of PEEK comprising the steps of:
- a) adding in a solid state PEEK and Combeite to a screw extruder to form an extrudable material;
- wherein the Combeite has a particle size range from 1 μm to 300 μm, and wherein the Combeite comprises from 10% to 50% by weight of the extrudable material;
- and
- b) applying heat to the extrudable material to at least the melting temperature of the PEEK to melt mix the PEEK and Combeite;
- and
- c) extruding a bioactive composite.
A method that facilitates the mechanical interlock of a bioactive composite implant to bone comprising the steps of:
- a) implanting in host bone of an animal a composite implant comprised of PEEK and Combeite bioactive glass particles having a particle size range from 1 μm to 300 μm, wherein at least 50% of the Combeite bioactive glass particles have a particle size from about 50 μm to 300 μm;
- and
- b) allowing the implant to remain adjacent the host bone a period of time sufficient to enable the bioactive glass particles to react with the host bone, thereby facilitating the mechanical interlock of the bioactive composite to the bone.
Dependencies are inferred from the claim text.